Manchester City is about to find out it’s a lot harder to retain the English Premier League title than it is to win it. This isn’t to say they won’t defend the crown, but the league will almost certainly be a lot closer than last season, especially with key midfielder Kevin De Bruyne expected to be out of action for three months with a knee injury. City lost just two league games last season and ran away with the title by 19 points ahead of runners up Manchester United.

Bet on Premier League Soccer at bet365

The latest bet365 odds as of September 10 has City listed at 4/6 to win the league for the second straight year.

Liverpool, who spent tons of cash during the offseason to strengthen their squad, are next favorites at 11/4. They’re followed by Chelsea, with new manager Maurizio Sarri at the helm, at 10/1 and Tottenham Hotspur, who stood pat during the transfer window, at 16/1.

Of course, some clubs are just happy to finish in the top four — and reap the benefits of European Champions League qualification and cash and Manchester United could be one of those squads in 2018/19. The team’s in a bit of turmoil as manager Jose Mourinho has told midfield maestro Paul Pogba to request a transfer if he wants to leave the club for a second time. This doesn’t bode well for United and their odds of taking the title are a whopping 40/1.

The odds of England’s other big-six team is even worse. Arsenal begins life without former manager Arsene Wenger for the first time in 22 years at just 50/1.

Things drop off drastically after that as surprising Watford is next at 250/1.

Leicester City, the surprise Premier League champions of 2015/16 are 500/1 along with newly-promoted Wolverhampton Wanderers and Everton.

There are several mediocre clubs in the division and their odds of winning the league represent this. We see West Ham United, Brighton & Hove Albion, Bournemouth, Southampton, Newcastle United, Crystal Palace and newly-promoted Fulham all listed at 1000/1.

These aren’t the worst of the bunch though as Burnley FC and Huddersfield are each listed at 1500/1 and the lone Welsh club, newly-promoted Cardiff, as the long shots at 3000/1.

Note: Odds were correct at the time of publishing but are subject to change.